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Factor V Leiden (G1691A), Factor V R2 (A4070G), and Prothrombin (G20210A) Genetic Polymorphisms in Macedonian Patients with Occlusive Artery Disease and Deep Vein Thrombosis

South East European Journal of Cardiology

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Title Factor V Leiden (G1691A), Factor V R2 (A4070G), and Prothrombin (G20210A) Genetic Polymorphisms in Macedonian Patients with Occlusive Artery Disease and Deep Vein Thrombosis
 
Creator Spiroski, Igor
Kedev, Sashko
Efinska-Mladenovska, Olivija
 
Subject Medicine
Factor V Leiden (G1691A); Factor V R2 (A4070G); Prothrombin (G20210A); genetic polymorphisms; occlusive artery disease; deep venous thrombosis; Macedonians
Cardiology
 
Description AIM: The aim was to analyze association of Factor V Leiden (G1691A), Factor V R2 (A4070G), and Prothrombin (G20210A) Genetic Polymorphism in Macedonian Patients with Occlusive Artery Disease (OAD) and Deep Vein Thrombosis (DVT).METHODS: Investigated groups consists of 82 healthy, 76 patients with OAD, and 67 patients with DVT. Blood samples were collected after written consent, and DNA was isolated from peripheral blood leukocytes. Identification of Factor V Leiden (G1691A), Factor V R2 (A4070G), and Prothrombin (G20210A) Genetic Polymorphism was done with CVD StripAssay (ViennaLab, Labordiagnostica GmbH, Austria). The population genetics analysis package, PyPop, was used for analysis of the data. Pearson's P-values, crude Odds Ratio and Wald’s 95% CI were calculated.RESULTS: The frequency of G allele for Factor V Leiden was 0.976 for healthy participants, 0.954 for OAD, and 0.948 for DVT. The frequency of A allele for Factor R2 is highest in healthy participants (0.951), smaller in patients with DVT (0.918), and smallest in the patients with OAD (0.908). G allele frequency for prothrombin was 0.976 in healthy participants, 0.980 in patients with OAD, and 0.978 in patients with DVT. Test of neutrality (Fnd) showed positive value, but was not significantly different from 0.  Factor V Leiden (G1691A), Factor R2 (A4070G), and Prothrombin (G20210A) genotypes in healthy participants and patients with OAD and DVT were in Hardy Weinberg proportions. Any association of Factor V Leiden (G1691A), Factor R2 (A4070G), and Prothrombin (G20210A) genetic polymorphism with OAD, and DVT in Macedonians was not found.CONCLUSION: We conclude that significant association of Factor V Leiden (G1691A), Factor R2 (A4070G), and Prothrombin (G20210A) genetic polymorphism with occlusive artery disease or deep venous thrombosis in Macedonians was not found.
 
Publisher ID Design 2012/DOOEL Skopje, Republic of Macedonia
 
Contributor
 
Date 2015-08-22
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Identification of Factor V Leiden (G1691A), Factor V R2 (A4070G), and Prothrombin (G20210A) Genetic Polymorphism was done with CVD StripAssay (ViennaLab, Labordiagnostica GmbH, Austria)
 
Format application/pdf
 
Identifier http://www.id-press.eu/seejca/article/view/362
10.3889/seejca.2015.30001
 
Source South East European Journal of Cardiology; Vol 2015 (2015): 2015
1857-9361
 
Language eng
 
Relation http://www.id-press.eu/seejca/article/view/362/485
 
Coverage Macedonia
2015
Investigated groups consists of 82 healthy, 76 patients with OAD, and 67 patients with DVT
 
Rights Copyright (c) 2015 Igor Spiroski, Sashko Kedev, Olivija Efinska-Mladenovska
http://creativecommons.org/licenses/by-nc/4.0